Acute Pancreatitis is an inflammatory process of variable severity; most episodes of acute pancreatitis are self-limiting and associated with mild transitory symptoms that remit with in 3 to 5 days.
What is the Etiology of acute pancreatitis?
1. Gall stone
3. Drugs induces (Isoniazid, estrogen, thiazide, furosemide)
6. Infections (mumps, orchitis, Coxsackie’s virus B, E-B virus, Hepatitis A and B)
What is the Pathogenesis of Acute Pancreatitis?
The exact Mechanism is still unclear. However, the chain of events beings and pancreatic acinar cell injury. Afflicted acinar cells locally release activated pancreatic digestive enzymes that result in parenchymal autodigestion along with the recruitment of inflammatory cell mediators, eventually leading to a systemic inflammatory response.
What Pathological changes in Acute Pancreatitis?
The pathologic changes of acute pancreatitis include parenchymal and peripancreatic fat necrosis and an associated inflammatory reaction.
How to diagnosed acute pancreatitis?
Diagnosis relies on patient history, physical examination, laboratory studies and radiological imaging.
Laboratory studies include:
Radiologic Imaging includes:
What are the complications of acute pancreatitis?
What are the Differential diagnoses of acute pancreatitis?
How to managed acute pancreatitis?
Surgical treatment is needed for the small percentage of patients who continue to deteriorate despite aggressive supportive therapy, but there is not a clear indication for surgical intervention.
Surgical procedure includes:
What is the prognosis of acute pancreatitis?
Prognosis depends upon Ranson criteria;
Ranson’s criteria are useful in assessing prognosis in early acute pancreatitis. The more of the criteria are met the higher the mortality. Ranson’s criteria are assessed both at admission and at 48 hours.
Ranson criteria include:
Admission Risk Factors
At 48 hours Risk Factors
This blog post was originally published by AutoimmuneMom.com, written by Emedicinezone.com, and first published on Sep 3, 2010.