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Castleman disease (CD)

Castleman disease (CD)  is a rare disease of lymph nodes and related tissues. It is also called giant lymph node hyperplasia, and angiofollicular lymph node hyperplasia (AFH). Castleman disease can occur in a localized (unicentric) or widespread (multicentric) form. It was first described by Dr. Benjamin Castleman in the 1950s. CD is not cancer. Instead, it is called a lymphoproliferative disorder. This means there is an abnormal overgrowth of cells of the lymph system that is similar in many ways to lymphomas (cancers of lymph nodes). Treatment and outlook vary, depending on the type of Castleman disease you have. The localized type can usually be successfully treated with surgery. Sometimes associated with HIV infection, multicentric Castleman disease can be life-threatening. Multicentric Castleman disease is also associated with other cell-proliferation disorders, including Kaposi’s sarcoma and POEMS syndrome.

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