Chronic recurrent multifocal osteomyelitis (CRMO) Although its definition is still evolving, many doctors and articles describe CRMO as an autoimmune related disease. The origin of this disease however, is unclear. It is “multifocal” because it can erupt in different sites, primarily in bones. It is a rare condition (1:1,000,000). It comprises periodic bone pain, fever, and the appearance of multiple bone lesions that can occur in any skeletal site. Genetics appears to play a role, but the diagnosis can be difficult. Although adults can be affected, CRMO most often affects children, more commonly girls than boys. The peak age of incidence is around 10 years, with the range being 4 to 55 years. Children show symptoms ranging from pain, deep aching pain, limping, to fever. The metaphyseal area of long bones, the clavicle, and the shoulder girdle are common locations where CRMO is found. Other sites such as the spine, ankle, and foot have been reported. Dermatological (skin) manifestations may occur and include psoriasis, acne, and pustules on the palms of the hands and soles of the feet.