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IgG4-related sclerosing disease

IgG4-related sclerosing disease , also known as IgG4–related systemic disease (IgG4-RSD), hyper-IgG4 disease and IgG4-related disease is an autoimmune disease in which inflammatory cells cause fibrosis, the deposition of connective tissue, in one or more organs. The disease is so named because the antibody subtype IgG4 can be detected on tissue samples and often at elevated levels in the bloodstream. The association with IgG4 is a relatively recent finding, and the condition has been described under numerous other names in the past.

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