Schmidt syndrome also known as Polyglandular autoimmune syndrome type 2 is a rare autoimmune syndrome that commonly has the constellation of three diseases: diabetes mellitus type 1, hypothyroidism and adrenal insufficiency. Owing to the diabetes mellitus type 1, patients require life-long insulin therapy and blood glucose levels need to be monitored. They are at risk for chronic complications of diabetes such as neuropathy, nephropathy and retinopathy. More acutely, due to fluctuations in blood glucose levels, they are at risk for hypoglycemia with neuroglycopenic symptoms and ketoacidosis. Hypothyroidism is diagnosed by measuring the thyroid hormone levels and if inappropriately low is treated with replacement therapy. Patients with adrenal insufficiency experience symptoms due to low glucocorticoid and mineralocorticoid levels in the body, due to decreased or absent production.